Biomimetic synthesis, antimicrobial, antileishmanial and antimalarial activities of euglobals and their analogues

SB Bharate, KK Bhutani, SI Khan, BL Tekwani…

Index: Bharate, Sandip B.; Bhutani, Kamlesh K.; Khan, Shabana I.; Tekwani, Babu L.; Jacob, Melissa R.; Khan, Ikhlas A.; Singh, Inder Pal Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 6 p. 1750 - 1760

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Citation Number: 51

Abstract

In the present communication, naturally occurring phloroglucinol–monoterpene adducts, euglobals G1–G4 (3b/a and 4a/b) and 16 new analogues (13a/b–18a/b and 19–22) were synthesized by biomimetic approach. These synthetic compounds differ from natural euglobals in the nature of monoterpene and acyl functionality. All of these compounds were evaluated for their antibacterial, antifungal, antileishmanial and antimalarial activities. ...