Oxime carbonates: novel reagents for the introduction of fmoc and Alloc protecting groups, free of side reactions

…, R Subirós??Funosas, A El??Faham…

Index: Khattab, Sherine N.; Subiros-Funosas, Ramon; El-Faham, Ayman; Albericio, Fernando European Journal of Organic Chemistry, 2010 , # 17 p. 3275 - 3280

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Citation Number: 11

Abstract

Abstract Fmoc and Alloc protecting groups represent a consistent alternative to classical Boc protection in peptide chemistry. The former was established in the last decades as the α- amino protecting group of choice, whereas the latter allows a fully orthogonal protection strategy with Fmoc and Boc. Usually, the introduction of the Fmoc and Alloc moieties takes place through their halogenoformates, azides, or activated carbonates. This rather simple ...