Feeding the Heck Reaction with Alcohol: One??Pot Synthesis of Stilbenes from Aryl Alcohols and Bromides

…, M Purdie, K Mulholland, I Kozhevnikov…

Index: Colbon, Paul; Barnard, Jonathan H.; Purdie, Mark; Mulholland, Keith; Kozhevnikov, Ivan; Xiao, Jianliang Advanced Synthesis and Catalysis, 2012 , vol. 354, # 8 p. 1395 - 1400

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Citation Number: 6

Abstract

Abstract Aryl alcohols are employed as feedstock for the Heck reaction. Keggin-type heteropolyacids catalyse the selective dehydration of the alcohols to styrenes, which, in one- pot, undergo palladium-catalysed Heck arylation with aryl bromides, affording broadly functionalised stilbenes. The choice of solvent is critical for the cascade dehydration–Heck reaction, with electron-rich aryl alcohols preferring a basic medium while electron- ...