Tetrahedron

Palladium-catalyzed acylation and/or homo-coupling of aryl-and alkyl-acetylenes

S Perrone, F Bona, L Troisi

Index: Perrone, Serena; Bona, Fabio; Troisi, Luigino Tetrahedron, 2011 , vol. 67, # 38 p. 7386 - 7391

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Citation Number: 23

Abstract

Allyl or benzyl halides, through a Pd (0)-catalyzed reaction and under CO pressure, generate acyl-palladium/halides that, in the presence of a base and an aryl-and alkyl- acetylene, undergo nucleophilic acyl substitution giving conjugated acetylenic ketones. Diynes, resulting from alkyne/alkyne homo-coupling, were instead the main products in reactions performed without allyl or benzyl halides. Moreover, dimerization, trimerization, ...