Synthetic Reactions in PEG: PEG-Assisted Synthesis of 2-Cyano-6-methoxybenzothiazole, A Key Intermediate For The Synthesis of Firefly Luciferin

N Suzuki, T Nomoto, Y Toya, N Kanamori…

Index: Suzuki, Nobutaka; Nomoto, Tateo; Toya, Yoshiaki; Kanamori, Norio; Yoda, Binkoh; Saeki, Akio Bioscience, Biotechnology, and Biochemistry, 1993 , vol. 57, # 9 p. 1561 - 1562

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Citation Number: 9

Abstract

Polyethylene glycol (PEG), an excellent substitute for crown ethers, has been successfullly used as a co-solvent in some substitution reactions, 1-6) catalytic hydrogenations, 7, 8) oxidation reactions, S) and reductions. 9, 10) In this paper, we describe an improved and efficient synthesis of 2-cyano-6-methoxybenzothiazole (2), a key intermediate for firefly luciferin synthesis, from commercially available 2-amino-6-methoxybenzothiazole (4) by a ...