A Novel Application of Chloroperoxidase: Preparation of gem-Halonitro Compounds

…, AV Yabannavar, DR Dodds, CA Evans…

Index: Zaks, Aleksey; Yabannavar, Asha V.; Dodds, David R.; Evans, C. Anderson; Das, Pradip R.; Malchow, Rodney Journal of Organic Chemistry, 1996 , vol. 61, # 24 p. 8692 - 8695

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Citation Number: 21

Abstract

Conversion of carbonyl to nitro compounds is usually carried out in three or four steps via addition of hydroxylamine to ketones to form the corresponding oximes, oxidation of the oximes to halonitroso intermediates followed by ozonolysis, and halogen removal by catalytic hydrogenation (Scheme 1). 1 The second step of the transformation, chlorination of oximes to chloronitroso compounds, is achieved by a number of reagents including ...