Discovery and optimization of a novel class of orally active nonpeptidic endothelin-A receptor antagonists

H Riechers, HP Albrecht, W Amberg…

Index: Journal of Medicinal Chemistry, , vol. 39, # 11 p. 2123 - 2128

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Citation Number: 131

Abstract

... Journal of Medicinal Chemistry. ... Chemistry. The synthesis of compound 6 is shown in Scheme 1. Reaction of a symmetrically substituted benzophenone derivative (2) with methyl chloroacetate gave the glycidic ester 3 in 70−95% yield. ...

Discovery and optimization of a novel class of orally active...

[Riechers, Hartmut; Albrecht, Hans-Peter; Amberg, Willi; Baumann, Ernst; Bernard, Harald; Boehm, Hans-Joachim; Klinge, Dagmar; Kling, Andreas; Mueller, Stefan; Raschack, Manfred; Unger, Liliane; Walker, Nigel; Wernet, Wolfgang Journal of Medicinal Chemistry, 1996 , vol. 39, # 11 p. 2123 - 2128]