Bis (amidate) bis (amido) titanium complex: a regioselective intermolecular alkyne hydroamination catalyst

…, RO Ayinla, DC Leitch, LL Schafer

Index: Yim, Jacky C.-H.; Bexrud, Jason A.; Ayinla, Rashidat O.; Leitch, David C.; Schafer, Laurel L. Journal of Organic Chemistry, 2014 , vol. 79, # 5 p. 2015 - 2028

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Citation Number: 31

Abstract

An efficient and selective bis (amidate) bis (amido) titanium precatalyst for the anti- Markovnikov hydroamination of alkynes is reported. Hydroamination of terminal and internal alkynes with primary alkylamines, arylamines, and hydrazines is promoted by 5–10 mol% of Ti catalyst. Various functional groups are tolerated including esters, protected alcohols, and imines. The in situ generated complex shows comparable catalytic activity, demonstrating ...