Chemical Communications

Ruthenium catalysed N-alkylation of amines with alcohols

MHSA Hamid, JMJ Williams

Index: Hamid, Malai Haniti S. A.; Williams, Jonathan M. J. Chemical Communications, 2007 , # 7 p. 725 - 727

Full Text: HTML

Citation Number: 87

Abstract

The alkylation of amines often involves treatment of the amine with an alkyl halide or similar alkylating agent. However, there can be problems with the toxicity of such alkylating agents and control of mono-alkylation can be problematic. 1 An alternative approach to the synthesis of secondary amines involves reductive amination of carbonyl compounds . 2 An attractive combination of these methods employs alcohols as the starting materials, which undergo loss of ...