Tetrahedron letters

Convenient methods for the hydrolysis of oxazolidinones to vicinal aminoalcohols

SJ Katz, SC Bergmeier

Index: Katz, Steven J; Bergmeier, Stephen C Tetrahedron Letters, 2002 , vol. 43, # 4 p. 557 - 559

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Citation Number: 49

Abstract

We have developed two convenient methods for hydrolysis of 2-oxazolidinones to the corresponding vicinal aminoalcohols. N-Substituted oxazolidinones can be readily hydrolyzed using Dowex 1× 8-100 resin. N-Unsubstituted oxazolidinones cannot be hydrolyzed using Dowex resins but are effectively hydrolyzed using polymer supported ethylenediamine.