phenylethanolamine

Modify Date: 2024-01-02 19:23:50

phenylethanolamine Structure
phenylethanolamine structure
Common Name phenylethanolamine
CAS Number 7568-93-6 Molecular Weight 137.179
Density 1.1±0.1 g/cm3 Boiling Point 286.9±13.0 °C at 760 mmHg
Molecular Formula C8H11NO Melting Point 56-58 °C(lit.)
MSDS Chinese USA Flash Point 151.4±10.5 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of phenylethanolamine


2-Amino-1-phenylethanol is an analogue of noradrenaline.

 Names

Name phenylethanolamine
Synonym More Synonyms

 phenylethanolamine Biological Activity

Description 2-Amino-1-phenylethanol is an analogue of noradrenaline.
Related Catalog
Target

Human Endogenous Metabolite

References

[1]. Melandri S, et al. Shape of biomolecules by free jet microwave spectroscopy: 2-amino-1-phenylethanol and 2-methylamino-1-phenylethanol. J Phys Chem A. 2009 Jul 9;113(27):7769-73.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 286.9±13.0 °C at 760 mmHg
Melting Point 56-58 °C(lit.)
Molecular Formula C8H11NO
Molecular Weight 137.179
Flash Point 151.4±10.5 °C
Exact Mass 137.084061
PSA 46.25000
LogP 0.82
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.600
Stability Stable. Incompatible with oxidizing agents, acids, acid chlorides, acid anhydrides.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DN5500000
CHEMICAL NAME :
Benzyl alcohol, alpha-(aminomethyl)-
CAS REGISTRY NUMBER :
7568-93-6
BEILSTEIN REFERENCE NO. :
0971222
LAST UPDATED :
199701
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C8-H11-N-O
MOLECULAR WEIGHT :
137.20
WISWESSER LINE NOTATION :
Z1YQR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
686 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 47,96,1934
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1100 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - sympathomimetic
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 153,161,1930
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
23 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 47,96,1934
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948 Volume(issue)/page/year: -,73,1948 *** REVIEWS *** TOXICOLOGY REVIEW CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924- Volume(issue)/page/year: 9,389,1931

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS DN5500000

 Synthetic Route

 Articles33

More Articles
A quantum dot based electrochemiluminescent immunosensor for the detection of pg level phenylethanolamine A using gold nanoparticles as substrates and electron transfer accelerators.

Analyst 139(17) , 4365-72, (2014)

This study reports the development of an electrochemiluminescent (ECL) immunosensor for ultrasensitive detection of phenylethanolamine A (PA) based on CdSe quantum dots (QDs) and gold nanoparticles (G...

Development and validation of a sensitive method for simultaneous determination of eight β₂-agonists in pork by ultrasonic-assisted extraction and liquid chromatography/tandem mass spectrometry.

J. Chromatogr. Sci. 53(1) , 104-11, (2014)

A simple and sensitive ultrasonic-assisted extraction coupled with liquid chromatography-tandem quadrupole mass spectrometry was developed for the simultaneous determination of eight β2-agonists (i.e....

Simultaneous determination of plasma phenethylamine, phenylethanolamine, tyramine and octopamine by high-performance liquid chromatography using derivatization with fluorescamine.

J. Chromatogr. A. 427(2) , 320-5, (1988)

 Synonyms

Ethanol, 2- (phenylamino)-
β-Anilinoethanol
a-(Aminomethyl)benzyl alcohol
α-(Aminomethyl)benzyl alcohol
EINECS 231-469-1
N-(β-hydroxy)ethylaniline
phenylethanolamine
Aniline, N-(β-hydroxyethyl)-
b-Hydroxyphenethylamine
Ethanol, 2-(phenylamino)-
β-Hydroxyphenethylamine
2-(phenylamino)ethanol
N-(β-Hydroxyethyl)aniline
β-hydroxy-Phenethylamine
2-Anilinoethanol
Benzenemethanol, α-(aminomethyl)-
dl-β-Phenyl-β-hydroxyethylamine
α-(Aminomethyl)benzenemethanol
β-hydroxy-β-phenyl-Ethylamine
(±)-phenylethanolamine
N-2-hydroxyethylaniline
2-Amino-1-phenylethanol
MFCD00008137
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