Tetrahedron letters

Synthesis of functionally substituted unsymmetrical biaryls via a novel double metal catalyzed coupling reaction

JA Miller, RP Farrell

Index: Miller, Joseph A.; Farrell, Robert P. Tetrahedron Letters, 1998 , vol. 39, # 40 p. 7275 - 7278

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Citation Number: 63

Abstract

Unsymmetrical biaryls containing “reactive” functional groups (eg, nitrile or ester groups) can be synthesized in an efficient manner by the direct Ni-or Pd-catalyzed coupling of aryl halides (X= Cl, Br, I) with aryl Grignard (or-lithium) reagents, provided that a catalytic amount of a Zn or Cd salt is also present.