Highly efficient dehydration of carbohydrates to 5-(chloromethyl) furfural (CMF), 5-(hydroxymethyl) furfural (HMF) and levulinic acid by biphasic continuous flow …

M Brasholz, K Von Kaenel, CH Hornung, S Saubern…

Index: Brasholz, Malte; Von Kaenel, Karin; Hornung, Christian H.; Saubern, Simon; Tsanaktsidis, John Green Chemistry, 2011 , vol. 13, # 5 p. 1114 - 1117

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Citation Number: 47

Abstract

Using a continuous flow reactor, the dehydration of D-fructose and other carbohydrates to 5- (chloromethyl) furfural (1) is achieved in reaction times as short as 60 s. The biphasic flow process allows for high-yielding multigram scale production of CMF (1) which is obtained with excellent purity after a simple extractive work-up. Efficient conversion of D-fructose into 5-(hydroxymethyl) furfural (2) and levulinic acid (6) is also demonstrated using flow reactor ...