International Journal of Pharmaceutics 2014-12-10

Study of the persistence of the anti-inflammatory effect observed after application of preparations containing organic ultraviolet filters.

C Couteau, C Chauvet, E Paparis, L J M Coiffard

Index: Int. J. Pharm. 476(1-2) , 160-3, (2015)

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Abstract

Given that previous studies have highlighted the anti-inflammatory nature, which is influenced by UV radiation, of a certain number of ultraviolet filters currently used in Europe, it seemed interesting to evaluate the persistence of this type of effect. The persistence of the anti-inflammatory effect of fourteen preparations, each containing one of the ultraviolet filters authorized by Regulation (CE) No. 1223/2009, and of 10 commercially-available sun products was studied using the phorbol-myristate-acetate test on mice, up to 6 and a half hours after application. We can observe that a benzophenone, oxybenzone, a PABA derivative, octyldimethylPABA and a derivative of cinnamic acid, OMC as well as 3 commercially-available products, display a very marked anti-inflammatory effect at the end of our experimentation phase. The type of effect observed could encourage users to prolong the time that they are exposed to the sun, due to there being no warning signs, namely sunburn. Copyright © 2014 Elsevier B.V. All rights reserved.