Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives

D Sharma, B Narasimhan, P Kumar, V Judge…

Index: Sharma, Deepika; Narasimhan, Balasubramanian; Kumar, Pradeep; Judge, Vikramjeet; Narang, Rakesh; De Clercq, Erik; Balzarini, Jan European Journal of Medicinal Chemistry, 2009 , vol. 44, # 6 p. 2347 - 2353

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Citation Number: 101

Abstract

In the present study, we have synthesized 2-(substituted phenyl)-1H-imidazole (1–12) and (substituted phenyl)-[2-(substituted phenyl)-imidazol-1-yl]-methanone (13–26) analogues and screened them for their antimicrobial activity against Gram positive, Gram negative and fungal species. The results of antibacterial study indicated that compounds 15, 17 and 24 showed appreciable antibacterial activity and compound 26 emerged as the most ...