Biochemical and Biophysical Research Communications 1997-01-01

A unique mechanism of curcumin inhibition on F1 ATPase

Mizuki Sekiya, Ryosuke Hisasaka, Atsuko Iwamoto-Kihara, Masamitsu Futai, Mayumi Nakanishi-Matsui

Index: Biochem. Biophys. Res. Commun. 452(4) , 940-4, (2014)

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Abstract

• Polyphenols lowered the rotation rate of F1 ATPase by increasing catalytic dwell. • Curcumin showed different inhibitory mechanism from other polyphenols. • γ subunit carboxyl terminus is not required for curcumin binding. • Curcumin and γ subunit S174F mutation showed a synergistic effect.