Toxicology Letters 2014-04-21

Evaluation of the stereoselective biotransformation of permethrin in human liver microsomes: Contributions of cytochrome P450 monooxygenases to the formation of estrogenic metabolites

Ramon Lavado, Jiwen Li, John M. Rimoldi, Daniel Schlenk

Index: Toxicol. Lett. 226(2) , 192-7, (2014)

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Abstract

• Permethrin undergoes stereoselective oxidase and esterase metabolism in human liver microsomes. • Sequential metabolism from the esterase cleavage product PBOH to the oxidized product 3,4-PBOH is stereoselective for 1R-trans PM. • 1S-cis PM consistently has the least efficient turnover. • Cytochrome P450s catalyze both esterase and oxidase activities. • CYP2C19 has greater catalytic activity than CYP3A4 and stereoselectively catalyzes the transformation of 1R-trans PM.