Chemico-Biological Interactions 2013-05-25

Bisphenol A affects androgen receptor function via multiple mechanisms

Christina Teng, Bonnie Goodwin, Keith Shockley, Menghang Xia, Ruili Huang, John Norris, B. Alex Merrick, Anton M. Jetten, Christopher P. Austin, Raymond R. Tice

Index: Chem. Biol. Interact. 203(3) , 556-64, (2013)

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Abstract

• BPA antagonizes AR function by competitive inhibition of androgen binding. • Prevents functional foci formation in the nucleus. • Reduce the AR presence in the nucleus. • BPAF have similar activation function in ERα and inhibition in AR as BPA. • BPS is a weaker ERα agonist and does not inhibit AR function.