Chemical Communications 2012-09-18

Total synthesis of ascididemin via anionic cascade ring closure.

Ida Nymann Petersen, François Crestey, Jesper Langgaard Kristensen

Index: Chem. Commun. (Camb.) 48(72) , 9092-4, (2012)

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Abstract

A new and convergent synthesis of ascididemin is presented. Using an anionic cascade ring closure as the key step, this natural product is obtained in 45% overall yield in just 6 steps starting from 2'-fluoroacetophenone. This new approach was extended to the synthesis of a new isomer of ascididemin.