Recenti progressi in medicina 2013-04-01

[Prevention of post-operative recurrence in Crohn's disease: a critical review of randomized controlled trials and meta-analyses of different therapeutic strategies].

Giovanna Margagnoni, Valeria Clemente, Annalisa Aratari, Federica Fascì Spurio, Angela Maria De Gregorio, Annalisa Spagnolo, Maurizio Koch, Claudio Papi

Index: Recenti Prog. Med. 104(4) , 168-76, (2013)

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Abstract

Surgery is an almost inevitable event in Crohn's disease but is not curative; post-operative recurrence follows a sequential and predictable course. Prevention of post-operative recurrence in Crohn's disease is therefore a relevant problem in the management of the disease. Several drugs have been evaluated to decrease the risk of recurrence: these include mesalazine, antibiotics, probiotics, budesonide, thiopurines and biologic agents. This review focuses on the randomised controlled trials and meta-analyses addressing different drugs and strategies for preventing post-operative recurrence in Crohn's disease.