Budesonide
Budesonide structure
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Common Name | Budesonide | ||
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| CAS Number | 51333-22-3 | Molecular Weight | 430.534 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 599.7±50.0 °C at 760 mmHg | |
| Molecular Formula | C25H34O6 | Melting Point | 221-232ºC (dec.) | |
| MSDS | Chinese USA | Flash Point | 201.8±23.6 °C | |
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Processing of pharmaceutical materials by electrospraying under reduced pressure.
Drug Dev. Ind. Pharm. 41(1) , 116-23, (2014) Electrospraying was used in drug particle production.The aim of the research was to evaluate the possibilities to produce drug particles with desired pharmaceutical properties by electrospraying. In particular, the effect of drying pressure on particle proper... |
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In Vitro Assessment of Uptake and Lysosomal Sequestration of Respiratory Drugs in Alveolar Macrophage Cell Line NR8383.
Pharm. Res. 32 , 3937-51, (2015) To assess accumulation and lysosomal sequestration of 9 drugs used in respiratory indications (plus imipramine as positive control) in the alveolar macrophage (AM) cell line NR8383.For all drugs, uptake at 5 μM was investigated at 37 and 4°C to delineate acti... |
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Bsm1 vitamin D receptor polymorphism and calcium homeostasis following bariatric surgery.
J. Invest. Surg. 28(1) , 8-17, (2015) To evaluate the association between the Bsm1 vitamin D receptor polymorphism and the calcium-vitamin D-parathormone axis following bariatric surgery.This cross-sectional study included 86 morbidly obese patients, who underwent either gastric bypass or sleeve ... |
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The use of hydrazine-based derivatization reagents for improved sensitivity and detection of carbonyl containing compounds using MALDI-MSI.
Anal. Bioanal. Chem 407(8) , 2085-94, (2015) Hydrazine-based derivatization reagents have been used to detect the presence of the carbonyl containing glucocorticoid fluticasone proprionate in rat lung tissue by MALDI-MSI. Such reagents also act as a matrix for analysis by MALDI-MS and have been termed "... |
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Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease.
Brain 138 , 3221-37, (2015) Polyglutamine diseases are a class of dominantly inherited neurodegenerative disorders for which there is no effective treatment. Here we provide evidence that activation of serotonergic signalling is beneficial in animal models of Machado-Joseph disease. We ... |
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Dietary galacto-oligosaccharides prevent airway eosinophilia and hyperresponsiveness in a murine house dust mite-induced asthma model.
Respir. Res. 16 , 17, (2015) Allergic asthma is strongly associated with the exposure to house dust mite (HDM) and is characterized by eosinophilic pulmonary inflammation and airway hyperresponsiveness (AHR). Recently, there is an increased interest in using dietary oligosaccharides, als... |
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Immunomodulatory effects of galectin-1 on an IgE-mediated allergic conjunctivitis model.
Invest. Ophthalmol. Vis. Sci. 56(2) , 693-704, (2015) Galectin (Gal)-1, a lectin found at sites of immune privilege with critical role in the inflammation, has been poorly investigated in the ocular inflammatory diseases. Here, we evaluated the therapeutic potential of Gal-1 in ocular allergy using a model of ov... |
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Permeation of Therapeutic Drugs in Different Formulations across the Airway Epithelium In Vitro.
PLoS ONE 10 , e0135690, (2015) Pulmonary drug delivery is characterized by short onset times of the effects and an increased therapeutic ratio compared to oral drug delivery. This delivery route can be used for local as well as for systemic absorption applying drugs as single substance or ... |
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[Prevention of post-operative recurrence in Crohn's disease: a critical review of randomized controlled trials and meta-analyses of different therapeutic strategies].
Recenti Prog. Med. 104(4) , 168-76, (2013) Surgery is an almost inevitable event in Crohn's disease but is not curative; post-operative recurrence follows a sequential and predictable course. Prevention of post-operative recurrence in Crohn's disease is therefore a relevant problem in the management o... |
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Efficacy of budesonide in collagenous colitis Evaluation of: Miehlke S, Madisch A, Kupcinskas L, et al. Budesonide is more effective than mesalamine or placebo in short-term treatment of collagenous colitis. Gastroenterology 2014;146(5):1222-1230 e1222.
Expert Opin. Pharmacother. 15(15) , 2277-9, (2014) Collagenous colitis (CC) is a less common colonic disease with variable prevalence and undulating course. Among the available therapies, budesonide was demonstrated to induce a rapid and sustained remission in many cases, but little is known about the compara... |