Scope and utility of a new soluble copper catalyst [CuBr-LiSPh-LiBr-THF]: A comparison with other copper catalysts in their ability to couple one equivalent of a …

…, JD Miller, HK Chan, MO Delaney

Index: Burns, Dennis H.; Miller, Jeffrey D.; Chan, Ho-Kit; Delaney, Michael O. Journal of the American Chemical Society, 1997 , vol. 119, # 9 p. 2125 - 2133

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Citation Number: 92

Abstract

A mixture of equal amounts of CuBr-SMe2, LiBr, and LiSPh in THF at 0° C furnished a new soluble copper catalyst that was highly efficient at coupling primary, secondary, tertiary, aryl, vinyl, and allylic Grignard reagents to primary tosylates and primary Grignard reagents to secondary tosylates and mesylates, all with the use of only 1 equiv of Grignard reagent. The new catalyst was shown to be much more reactive than copper catalysts CuBr and ...