Antihyperglycemic activity of novel substituted 3H-1, 2, 3, 5-oxathiadiazole 2-oxides

…, TT Nguyen, JD Tomer, F Guzzo, JF Bagli…

Index: Ellingboe; Alessi; Dolak; Nguyen; Tomer; Guzzo; Bagli; McCaleb Journal of Medicinal Chemistry, 1992 , vol. 35, # 7 p. 1176 - 1183

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Citation Number: 47

Abstract

27 28 29 (a) H2, 10% Pd/C, EtOH.(b)(EtO) 2P (0) CH2CN, NaH, THF.(c) NaBH,, MeOH, THF.(d) KCN, 18-crown-6, nBu, P, CC,, acetonitrile. of a 2-methylbenzofuran (9a, 17 9b, or 90'~) or 2-methylbewthiophene (9dt8%, ls 9ft8 or 9gm) prepared according to Anderson, 18 and subsequent displacement with cyanide (method C). The chloromethylation and cyanide displacement reactions (method D) were utilized in the preparation of a number of ...