Environmental Toxicology and Pharmacology 2013-09-01

Antifibrotic activity of galangin, a novel function evaluated in animal liver fibrosis model.

Xinhui Wang, Guoqing Gong, Wenhui Yang, Yunzhan Li, Meiling Jiang, Linlin Li

Index: Environ. Toxicol. Pharmacol. 36(2) , 288-95, (2013)

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Abstract

This study aimed to investigate the effects of galangin on liver fibrosis in rats induced by subcutaneous injection of carbon tetrachloride (CCl4). The administration of CCl4 to rats for 12 weeks caused significant increase of hyaluronic acid, laminin, alanine transaminase, aspartate transaminase and decrease of total protein, albumin in serum, while the influences could be reversed by galangin. Galangin markedly reduced hepatic malondialdehyde, hydroxyproline concentration, increased activities of liver superoxide dismutase, glutathione peroxidase compared with CCl4-treated rats. Histological results indicated that galangin alleviated liver damage. In addition, treatment with galangin significantly down-regulated expressions of α-smooth muscle actin and transforming growth factor β1. These results suggest galangin can inhibit liver fibrosis induced by CCl4 in rats, which was probably associated with its effect on removing oxygen free radicals, decreasing lipid peroxidation, as well as inhibiting hepatic stellate cells activation and proliferation. Copyright © 2013 Elsevier B.V. All rights reserved.