Galangin
Galangin structure
|
Common Name | Galangin | ||
|---|---|---|---|---|
| CAS Number | 548-83-4 | Molecular Weight | 270.237 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 518.6±50.0 °C at 760 mmHg | |
| Molecular Formula | C15H10O5 | Melting Point | 214-215 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 202.0±23.6 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of GalanginGalangin is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | galangin |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Galangin is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity. |
|---|---|
| Related Catalog | |
| In Vitro | Galangin inhibits the catabolic breakdown of DMBA, as measured by thin-layer chromatography, in a dose-dependent manner. Galangin also inhibits the formation of DMBA-DNA adducts, and prevents DMBA-induced inhibition of cell growth. Galangin causes a potent, dose-dependent inhibition of CYP1A1 activity, as measured by ethoxyresorufin-O-deethylase activity, in intact cells and in microsomes isolated from DMBA-treated cells. Analysis of the inhibition kinetics by double-reciprocal plot demonstrates that galangin inhibits CYP1A1 activity in a noncompetitive manner. Galangin causes an increase in the level of CYP1A1 mRNA, indicating that it may be an agonist of the aryl hydrocarbon receptor, but it inhibits the induction of CYP1A1 mRNA by DMBA or by 2,3,5,7-tetrachlorodibenzo-p-dioxin (TCDD). Galangin also inhibits the DMBA- or TCDD-induced transcription of a reporter vector containing the CYP1A1 promoter[1]. Galangin treatment inhibits cell proliferation and induced autophagy (130 μM) and apoptosis (370 μM). In particular, galangin treatment in HepG2 cells causes (1) an accumulation of autophagosomes, (2) elevated levels of microtubule-associated protein light chain 3, and (3) an increased percentage of cells with vacuoles. p53 expression is also increased. The galangin-induced autophagy is attenuated by the inhibition of p53 in HepG2 cells, and overexpression of p53 in Hep3B cells restored the galangin-induced higher percentage of cells with vacuoles to normal level[2]. |
| Cell Assay | Cells (5.0×103) are seeded and treated with different concentrations of galangin for different periods of time in 96-well plates. The number of viable cells in each well is determined by adding 10 µL of 5 mg/mL MTT solution. Following the 4 hour incubation at 37°C, the cells are dissolved in a 100 µL solution containing 20% SDS and 50% dimethy formamide. The optical densities are quantified at a test wavelength of 570 nm with a reference wavelength of 630 nm using a Varioskan Flash Reader spectrophotometer. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 518.6±50.0 °C at 760 mmHg |
| Melting Point | 214-215 °C(lit.) |
| Molecular Formula | C15H10O5 |
| Molecular Weight | 270.237 |
| Flash Point | 202.0±23.6 °C |
| Exact Mass | 270.052826 |
| PSA | 90.90000 |
| LogP | 2.83 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.748 |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
|
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | LK9275500 |
| HS Code | 2914400090 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 8 | |
|---|---|
| DownStream 9 | |
CAS#:26964-29-4
CAS#:500-99-2
CAS#:17874-42-9
CAS#:82451-30-7
CAS#:480-66-0
CAS#:100-52-7
CAS#:65982-77-6
CAS#:93-97-0
CAS#:487-70-7
CAS#:65-85-0
CAS#:1707-75-1
CAS#:83-30-7
CAS#:480-14-8
CAS#:70786-48-0
CAS#:6665-74-3
CAS#:42193-83-9
CAS#:144-62-7This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2914400090 |
|---|---|
| Summary | 2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
|
Protective Effect of Plantago major Extract against t-BOOH-Induced Mitochondrial Oxidative Damage and Cytotoxicity.
Molecules 20 , 17747-59, (2015) Plantago major L. produces several chemical substances with anti-inflammatory and analgesic activities and its use in the treatment of oral and throat inflammation in popular medicine is well describe... |
|
|
Ultra high performance liquid chromatography with mass spectrometry method for the simultaneous determination of phenolic constituents in honey from various floral sources using multiwalled carbon nanotubes as extraction sorbents.
J. Sep. Sci. 38 , 2597-606, (2015) An ultra high performance liquid chromatography with mass spectrometry method has been developed for the simultaneous separation, identification and determination of 22 phenolic constituents in honey ... |
|
|
Combined experimental and in silico approaches for exploring antiperoxidative potential of structurally diverse classes of antioxidants on docetaxel-induced lipid peroxidation using 4-HNE as the model marker.
Bioorg. Chem. 56 , 1-7, (2014) The objective of the present work was tantamount to explain the antiperoxidative potential and structural requirements of twenty-eight structurally diverse classes of antioxidants on docetaxel-induced... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
|
Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
|
|
Name: Antioxidant activity assessed as inhibition of DPPH radical production at 33 uM after...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3056854
|
|
Name: Inhibition of human liver FBP1 at 200 uM incubated for 5 mins by fluorescence method ...
Source: ChEMBL
Target: Fructose-1,6-bisphosphatase 1
External Id: CHEMBL4629675
|
|
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
|
|
Name: Selectivity ratio of IC50 for reduced carboxymethylated kappa-casein fibril formation...
Source: ChEMBL
Target: N/A
External Id: CHEMBL1070090
|
|
Name: Selectivity ratio of IC50 for reduced carboxymethylated kappa-casein fibril formation...
Source: ChEMBL
Target: N/A
External Id: CHEMBL1070091
|
|
Name: Antioxidant activity assessed as DDPH radical scavenging activity
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL1225535
|
|
Name: Inhibition of HCV NS3 helicase overexpressed in Escherichia coli BL21(DE3) assessed a...
Source: ChEMBL
Target: N/A
External Id: CHEMBL2060535
|
|
Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
|
|
Name: Inhibition of SARS coronavirus nsP13 helicase activity expressed in Escherichia coli ...
Source: ChEMBL
Target: N/A
External Id: CHEMBL2060534
|
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| EINECS 208-960-4 |
| 3,5,7-trihydroxyflavone |
| Galangin |
| teptochrysin |
| Galengin |
| 3,5,7-trihydroxy-2-phenyl-chromen-4-one |
| 3,5,7-trihydroxy-flavon |
| 3,5,7-Trihydroxy-2-phenyl-4H-chromen-4-one |
| 3,5,7-Trihydroxy-Flavone |
| galangine |
| 5,7-dihydroxyflavonol |
| NORIZALPININ |
| 3,5,7-trihydroxyfalvone |
| MFCD00006833 |
| 3,5,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What are the downstream products of galangin? |
| A: Related downstream products(CAS) of galangin: 487-70-7;65-85-0;1707-75-1;83-30-7;480-14-8;70786-48-0;6665-74-3;42193-83-9;144-62-7. |
| Q: What is the melting point of galangin? |
| A: Melting point of galangin is 214-215 °C(lit.). |
| Q: What is the polar surface area (PSA) of galangin? |
| A: Polar surface area (PSA) of galangin is 90.90000. |
| Q: What is the English name of galangin? |
| A: The English name of galangin is galangin. |
| Q: What is the CAS number of galangin? |
| A: CAS number of galangin is 548-83-4. |
| Q: What is the LogP of galangin? |
| A: LogP of galangin is 2.83. |
| Q: What is the safety information for galangin? |
| A: Safety information for galangin: S26-S37/39. |
| Q: What are the uses of galangin? |
| A: Main uses of galangin: Galangin is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity. |
| Q: What is the molecular formula of galangin? |
| A: Molecular formula of galangin is C15H10O5. |
| Q: What is the boiling point of galangin? |
| A: Boiling point of galangin is 518.6±50.0 °C at 760 mmHg. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| naturewill |
| Henan Tianfu Chemical Co., Ltd. |