Nanoscale 2015-03-07

In situ nanofabrication of hybrid PEG-dendritic-inorganic nanoparticles and preliminary evaluation of their biocompatibility.

Ana Sousa-Herves, Christian Sánchez Espinel, Amir Fahmi, África González-Fernández, Eduardo Fernandez-Megia

Index: Nanoscale 7(9) , 3933-40, (2015)

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Abstract

An in situ template fabrication of inorganic nanoparticles using carboxylated PEG-dendritic block copolymers of the GATG family is described as a function of the dendritic block generation, the metal (Au, CdSe) and metal molar ratio. The biocompatibility of the generated nanoparticles analysed in terms of their aggregation in physiological media, cytotoxicity and uptake by macrophages relates to the PEG density of the surface of the hybrids.