Phytomedicine 2013-03-15

Testing of Perilla frutescens extract and Vicenin 2 for their antispasmodic effect.

Eugen J Verspohl, Hajime Fujii, Kohei Homma, Sybille Buchwald-Werner

Index: Phytomedicine 20(5) , 427-31, (2013)

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Abstract

Gastrointestinal discomfort is frequently observed. The effects of Perilla frutescens extract and Vicenin 2 (a compound in this extract) were assayed in rat ileum with or without stimulation with acetylcholine or Ba(2+). Both had no direct spasmolytic effect, but both decreased acetylcholine- or Ba(2+)-induced contraction of rat ileum indicating an antispasmodic effect. This is valuable because effects were only observed when spasms were induced and may disturb the patient. The extract and the compound may be used to maintain and improve gut health.Copyright © 2012 Elsevier GmbH. All rights reserved.