Alexandre Yukio Saito, Rodrigo Antonio Ceschini Sussmann, Emilia Akemi Kimura, Maria Belen Cassera, Alejandro Miguel Katzin
Index: J. Pharm. Biomed. Anal. 111 , 100-3, (2015)
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Nerolidol is a naturally occurring sesquiterpene found in the essential oils of many types of flowers and plants. It is frequently used in cosmetics, as a food flavoring agent, and in cleaning products. In addition, nerolidol is used as a skin penetration enhancer for transdermal delivery of therapeutic drugs. However, nerolidol is hemolytic at low concentrations. A simple and fast GC-MS method was developed for preliminary quantification and assessment of biological interferences of nerolidol in mouse plasma after oral dosing. Calibration curves were linear in the concentration range of 0.010-5 μg/mL nerolidol in mouse plasma with correlation coefficients (r) greater than 0.99. Limits of detection and quantification were 0.0017 and 0.0035 μg/mL, respectively. The optimized method was successfully applied to the quantification of nerolidol in mouse plasma.Copyright © 2015 Elsevier B.V. All rights reserved.
