Preparative Biochemistry and Biotechnology 2013-01-01

One-pot synthesis of 2,4,5-trisubstituted imidazoles using [BPy]H2PO4, an efficient and recyclable catalyst.

Yuliang Zhang, Zhongqiang Zhou

Index: Prep Biochem Biotechnol. 43(2) , 189-96, (2013)

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Abstract

[BPy]H(2)PO(4) was easily prepared and used as an efficient and recyclable catalyst for the one-pot synthesis of 2,4,5-trisubstituted imidazoles under solvent-free conditions in good to excellent yields. Solvent-free conditions, simple experimental and workup procedures, and the use of a nontoxic, recyclable catalyst of an environmentally benign nature are remarkable features of the procedure.