Life Sciences 2013-12-01

Nicotinamide, a glucose-6-phosphate dehydrogenase non-competitive mixed inhibitor, modifies redox balance and lipid accumulation in 3T3-L1 cells.

Nayeli Torres-Ram__rez, LuisArturo Baiza-Gutman, Rebeca Garc__a-Macedo, Clara Ortega-Camarillo, Alejandra Contreras-Ramos, Rafael Medina-Navarro, Miguel Cruz, Miguel_ngel Ib__ez-Hern_ndez, Margarita D__az-Flores

Index: Life Sci. 93(25-26) , 975-85, (2013)

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Abstract

Excessive energy uptake of dietary carbohydrates results in their storage as fat and requires glucose-6-phosphate dehydrogenase (G6PD)-mediated NADPH production. We sought to assess whether the nicotinamide-induced reduction of G6PD activity might modulate redox balance and lipid accumulation in 3T3-L1 cells.