Phytotherapy Research 2009-08-01

Antifungal activity of Glycyrrhiza glabra extracts and its active constituent glabridin.

Atiya Fatima, Vivek K Gupta, Suaib Luqman, Arvind S Negi, J K Kumar, Karuna Shanker, Dharmendra Saikia, Suchita Srivastava, M P Darokar, Suman P S Khanuja

Index: Phytother Res. 23(8) , 1190-3, (2009)

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Abstract

Glabridin, an active constituent of Glycyrrhiza glabra roots, was found to be active against both yeast and filamentous fungi. Glabridin also showed resistance modifying activity against drug resistant mutants of Candida albicans at a minimum inhibitory concentration of 31.25-250 microg/mL. Although the compound was reported earlier to be active against Candida albicans, but this is the first report of its activity against drug resistant mutants.Copyright 2009 John Wiley & Sons, Ltd.