Glabridin
Modify Date: 2024-01-02 16:14:43
Glabridin structure
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Common Name | Glabridin | ||
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| CAS Number | 59870-68-7 | Molecular Weight | 324.37 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 518.6±50.0 °C at 760 mmHg | |
| Molecular Formula | C20H20O4 | Melting Point | 154-155ºC | |
| MSDS | Chinese USA | Flash Point | 267.4±30.1 °C | |
Use of GlabridinGlabridin is a natural isoflavan from Glycyrrhiza glabra, binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities[1][2]. |
| Name | glabridin |
|---|---|
| Synonym | More Synonyms |
| Description | Glabridin is a natural isoflavan from Glycyrrhiza glabra, binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities[1][2]. |
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| Related Catalog | |
| Target |
PPARγ:6.1 μM (EC50) |
| In Vitro | Glabridin binds to and activates PPARγ, with an EC50 of 6115 nM[1]. Glabridin (40, 80 μM) inhibits the proliferation of SCC-9 and SAS cell lines in a dose- and time-dependent manner after treatment for 24 and 48 h[2]. Glabridin (0-80 μM) also induces apoptosis, causes Sub-G1 cell cycle arrest in SCC-9 and SAS cell lines[2]. Glabridin (0, 20, 40, and 80 μM) dose-dependently activates caspase-3, −8, and −9 and increases PARP cleavage, significantly phosphorylates ERK1/2, JNK1/2, and p-38 MAPK in SCC-9 cells[2]. |
| In Vivo | Glabridin (50 mg/kg, p.o. once daily) shows potent anti-inflammatory activity, ameliorates the inflammatory alterations induced by Dextran sodium sulphate (DSS) in rats[3]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 518.6±50.0 °C at 760 mmHg |
| Melting Point | 154-155ºC |
| Molecular Formula | C20H20O4 |
| Molecular Weight | 324.37 |
| Flash Point | 267.4±30.1 °C |
| Exact Mass | 324.136169 |
| PSA | 58.92000 |
| LogP | 4.26 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.623 |
| Storage condition | room temp |
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Glabridin CAS#:59870-68-7 |
| Literature: Synthetic Communications, , vol. 44, # 4 p. 540 - 546 |
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Glabridin CAS#:59870-68-7 |
| Literature: Synthetic Communications, , vol. 44, # 4 p. 540 - 546 |
|
~%
Glabridin CAS#:59870-68-7 |
| Literature: Synthetic Communications, , vol. 44, # 4 p. 540 - 546 |
|
~%
Glabridin CAS#:59870-68-7 |
| Literature: Synthetic Communications, , vol. 44, # 4 p. 540 - 546 |
|
~%
Glabridin CAS#:59870-68-7 |
| Literature: Synthetic Communications, , vol. 44, # 4 p. 540 - 546 |
|
~%
Glabridin CAS#:59870-68-7 |
| Literature: Synthetic Communications, , vol. 44, # 4 p. 540 - 546 |
| HS Code | 2942000000 |
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Glabridin inhibits migration and invasion by transcriptional inhibition of matrix metalloproteinase 9 through modulation of NF-κB and AP-1 activity in human liver cancer cells.
Br. J. Pharmacol. 171(12) , 3037-50, (2014) High mortality and morbidity rates for hepatocellular carcinoma in Taiwan primarily result from uncontrolled tumour metastasis. Glabridin, a prenylated isoflavonoid of licorice (Glycyrrhiza glabra) ro... |
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Novel phytonutrient contributors to antioxidant protection against cardiovascular disease
Nutrition 28(6) , 605-10, (2012) The associations linking endothelial inflammation, endothelial oxidative stress, and atherogenesis and the potential for dietary phytonutrients to decrease the impact of these associations were assess... |
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Glabridin inhibits migration, invasion, and angiogenesis of human non-small cell lung cancer A549 cells by inhibiting the FAK/rho signaling pathway.
Integr. Cancer Ther. 10(4) , 341-9, (2011) This study reports the antimigration, anti-invasive effect of glabridin, a flavonoid obtained from licorice, in human non-small cell lung cancer A549 cells. Glabridin exhibited effective inhibition of... |
| 1,3-Benzenediol,4-(3,4-dihydro-8,8-dimethyl-2H,8H-benzo(1,2-b:3,4-b')dipyran-3-yl)-,(R) |
| 4-(3,4-Dihydro-8,8-dimethyl-2H,8H-benzo(1,2-b:3,4-b')dipyran-3-yl)-1,3-benzenediol |
| Glabridin |
| Bio-0904 |
| 4-[(3R)-8,8-dimethyl-3,4-dihydro-2H-pyrano[2,3-f]chromen-3-yl]benzene-1,3-diol |
| 4-[(3R)-8,8-Dimethyl-3,4-dihydro-2H,8H-pyrano[2,3-f]chromen-3-yl]benzene-1,3-diol |
| BIDD:ER0172 |
| 4-[(3R)-8,8-Dimethyl-3,4-dihydro-2H,8H-pyrano[2,3-f]chromen-3-yl]-1,3-benzenediol |
| 1,3-Benzenediol, 4-[(3R)-3,4-dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-3-yl]- |
| MFCD03427694 |
- BioBioPha
- China
- Product Name: Glabridin
- Price: ￥Inquiry/20mg
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Xueping-Zheng
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Glabridin
- Price: ￥548.0/20mg
- Purity: 98.0%
- Stocking Period: 2 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Glabridin
- Price: $300.0/100mg $600.0/250mg $1200.0/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Henan Tianfu Chemical Co., Ltd.
- China
- Product Name: Glabridin 90%(White powder)
- Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
- Purity: 99.0%
- Stocking Period: Inquiry
- Contact: Anson
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Price: ￥880/10 mM * 1 mL in DMSO
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