Tetrahedron letters

Photogeneration of highly electrophilic benzoylketene from dibenzoyldiazomethane in aqueous solvents: Reaction with amino acids and DNA cleavage

K Nakatani, J Shirai, R Tamaki, I Saito

Index: Nakatani, Kazuhiko; Shirai, Junya; Tamaki, Ryo; Saito, Isao Tetrahedron Letters, 1995 , vol. 36, # 30 p. 5363 - 5366

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Citation Number: 16

Abstract

Photoirradiation of dibenzoyldiazomethane in the presence of amino acid derivatives in aqueous solutions efficiently produced the addition products through a reaction with photogenerated benzoylketene. Efficient DNA cleavage was observed with a dibenzoyldiazomethane derivative, possessing a cationic side chain under photoirradiation conditions.