Bioorganic & Medicinal Chemistry Letters 2009-06-15

Natural product inhibitors of protein-protein interactions mediated by Src-family SH2 domains.

Bianca Sperl, Markus H J Seifert, Thorsten Berg

Index: Bioorg. Med. Chem. Lett. 19 , 3305-9, (2009)

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Abstract

In this Letter, we report the natural products salvianolic acid A, salvianolic acid B, and caftaric acid as inhibitors of the protein-protein interactions mediated by the SH2 domains of the Src-family kinases Src and Lck, two established disease targets. Moreover, we propose a binding mode for the inhibitors based on molecular modeling, which will facilitate chemical optimization efforts of these important lead structures for drug discovery.