Chlorogenic acid

Modify Date: 2025-08-21 19:23:49

Chlorogenic acid structure	Common Name	Chlorogenic acid
	CAS Number	327-97-9	Molecular Weight	354.309
	Density	1.7±0.1 g/cm3	Boiling Point	665.0±55.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₁₈O₉	Melting Point	210 °C (dec.)(lit.)
	MSDS	Chinese USA	Flash Point	245.5±25.0 °C

Use of Chlorogenic acid

Chlorogenic acid is a major phenolic compound in coffee and tea. It plays several important and therapeutic roles such as antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension.

Name	chlorogenic acid
Synonym	More Synonyms

Description	Chlorogenic acid is a major phenolic compound in coffee and tea. It plays several important and therapeutic roles such as antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase Research Areas >> Inflammation/Immunology Natural Products >> Phenylpropanoids
References	[1]. Park JJ, et al. Chlorogenic acid inhibits hypoxia-induced angiogenesis via down-regulation of the HIF-1α/AKT pathway. Cell Oncol (Dordr). 2015 Jan 6. [2]. Park SH, et al. IRAK4 as a Molecular Target in the Amelioration of Innate Immunity-Related Endotoxic Shock and Acute Liver Injury by Chlorogenic Acid. J Immunol. 2015 Feb 1;194(3):1122-30. [3]. Kang JW, et al. Protective Effects of Chlorogenic Acid against Experimental Reflux Esophagitis in Rats. Biomol Ther (Seoul). 2014 Sep;22(5):420-5.

Description

Related Catalog

Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase

Research Areas >> Inflammation/Immunology

Natural Products >> Phenylpropanoids

References

[1]. Park JJ, et al. Chlorogenic acid inhibits hypoxia-induced angiogenesis via down-regulation of the HIF-1α/AKT pathway. Cell Oncol (Dordr). 2015 Jan 6.

[2]. Park SH, et al. IRAK4 as a Molecular Target in the Amelioration of Innate Immunity-Related Endotoxic Shock and Acute Liver Injury by Chlorogenic Acid. J Immunol. 2015 Feb 1;194(3):1122-30.

[3]. Kang JW, et al. Protective Effects of Chlorogenic Acid against Experimental Reflux Esophagitis in Rats. Biomol Ther (Seoul). 2014 Sep;22(5):420-5.

Density	1.7±0.1 g/cm3
Boiling Point	665.0±55.0 °C at 760 mmHg
Melting Point	210 °C (dec.)(lit.)
Molecular Formula	C₁₆H₁₈O₉
Molecular Weight	354.309
Flash Point	245.5±25.0 °C
Exact Mass	354.095093
PSA	164.75000
LogP	-0.36
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.690
Water Solubility	SOLUBLE IN HOT WATER

Chlorogenic acid MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GU8480000

CHEMICAL NAME :: Cyclohexanecarboxylic acid, 3-((3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl)oxy)- 1,4,5-trihydroxy-, (1S-(1-alpha,3-beta,4-alpha,5-alpha))-

CAS REGISTRY NUMBER :: 327-97-9

LAST UPDATED :: 199712

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C16-H18-O9

MOLECULAR WEIGHT :: 354.34

WISWESSER LINE NOTATION :: L6TJ AQ BQ EVQ EQ COV1U1R CQ DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 40 mg/kg

SEX/DURATION :: female 5-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 250 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 111,209,1983

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi: Irritant;
Risk Phrases	R68
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	GU8480000

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3-Caffeoylquinate

5-caffeoylquinic acid

3-O-Caffeoylquinic acid

3-Caffeoylquinic acid

CHLOROGENIC ACID

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EINECS 206-325-6

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Chlorogenic acid

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