Elemental fluorine Part 12. Fluorination of 1, 4-disubstituted aromatic compounds

RD Chambers, J Hutchinson, ME Sparrowhawk…

Index: Chambers, Richard D.; Hutchinson, John; Sparrowhawk, Matthew E.; Sandford, Graham; Moilliet, John S.; Thomson, Julie Journal of Fluorine Chemistry, 2000 , vol. 102, # 1-2 p. 169 - 173

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Citation Number: 34

Abstract

The importance of fluorinated compounds, and fluorinated aromatic compounds in particular, to the agrochemical [1] and pharmaceutical [2] industries is well established. Industrially, fluoroaromatic compounds having fluorine attached directly to an aromatic ring are generally prepared by either a halogen exchange reaction (Halex) in which an 'activated' chlorine atom on an aromatic ring is replaced by fluorine using fluoride ion in a suitable solvent, or ...