Design and synthesis of novel 3, 5-bis-N-(aryl/heteroaryl) carbamoyl-4-aryl-1, 4-dihydropyridines as small molecule BACE-1 inhibitors

N Razzaghi-Asl, O Firuzi, B Hemmateenejad…

Index: Razzaghi-Asl, Nima; Firuzi, Omidreza; Hemmateenejad, Bahram; Javidnia, Katayoun; Edraki, Najmeh; Miri, Ramin Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 22 p. 6893 - 6909

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Citation Number: 8

Abstract

Abstract Alzheimer disease (AD) is a neuronal dementia for which no treatment has been consolidated yet. Major pathologic hallmark of AD is the aggregated extracellular amyloid-β plaques in the brains of disease sufferers. Aβ-peptide is a major component of amyloid plaques and is produced from amyloid precursor protein (APP) via the proteolysis action. An aspartyl protease known as β-site amyloid precursor protein cleaving enzyme (BACE-1) is ...