2-Aminothiazole

Modify Date: 2026-06-30 17:37:41

2-Aminothiazole structure	Common Name	2-Aminothiazole
	CAS Number	96-50-4	Molecular Weight	100.142
	Density	1.3±0.1 g/cm3	Boiling Point	216.4±9.0 °C at 760 mmHg
	Molecular Formula	C₃H₄N₂S	Melting Point	91-93 °C(lit.)
	MSDS	Chinese USA	Flash Point	84.7±18.7 °C
	Symbol	GHS07	Signal Word	Warning

Use of 2-Aminothiazole

Aminothiazole (2-Aminothiazole) is a beginning point for synthesis of many compounds including sulfur drugs, biocides, fungicides, dyes and chemical reaction accelerators.IC50 value:Target:2-Aminothiazole can be used as a thyroid inhibitor in the treatment of hyperthyroidism and it has antibacterial activity. Also used as the acid tartrate. Recent studies using prion-infected neuroblastoma cell lines have suggested that aminothiazole may be used as a therapeutic drug for prion diseases.

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	1,3-thiazol-2-amine
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Aminothiazole (2-Aminothiazole) is a beginning point for synthesis of many compounds including sulfur drugs, biocides, fungicides, dyes and chemical reaction accelerators.IC50 value:Target:2-Aminothiazole can be used as a thyroid inhibitor in the treatment of hyperthyroidism and it has antibacterial activity. Also used as the acid tartrate. Recent studies using prion-infected neuroblastoma cell lines have suggested that aminothiazole may be used as a therapeutic drug for prion diseases.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others
References	[1]. Gallardo-Godoy A, et al. 2-Aminothiazoles as therapeutic leads for prion diseases. J Med Chem. 2011 Feb 24;54(4):1010-21.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.3±0.1 g/cm3
Boiling Point	216.4±9.0 °C at 760 mmHg
Melting Point	91-93 °C(lit.)
Molecular Formula	C₃H₄N₂S
Molecular Weight	100.142
Flash Point	84.7±18.7 °C
Exact Mass	100.009521
PSA	67.15000
LogP	0.38
Vapour Pressure	0.1±0.4 mmHg at 25°C
Index of Refraction	1.645
InChIKey	RAIPHJJURHTUIC-UHFFFAOYSA-N
SMILES	Nc1nccs1
Water Solubility	100 g/L (20 ºC)

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

2-Aminothiazole MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XJ2100000

CHEMICAL NAME :: Thiazole, 2-amino-

CAS REGISTRY NUMBER :: 96-50-4

LAST UPDATED :: 199806

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C3-H4-N2-S

MOLECULAR WEIGHT :: 100.15

WISWESSER LINE NOTATION :: T5N CSJ BZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 480 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - coma Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 570 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - coma Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 370 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - coma Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - coma Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 4500 mg/kg/56D-I

TOXIC EFFECTS :: Liver - hepatitis (hepatocellular necrosis), zonal Liver - fatty liver degeneration Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 200 mg/m3/7H/61D-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Lungs, Thorax, or Respiration - dyspnea Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 200 mg/m3/7H/30D-I

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - chronic pulmonary edema Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 25 mg/m3/7H/62D-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - chronic pulmonary edema Liver - fatty liver degeneration Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - mouse Lymphocyte

DOSE/DURATION :: 557 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 155,17,1985

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22;R36/37
Safety Phrases	S26-S36/37-S39
RIDADR	2811
WGK Germany	3
RTECS	XJ2100000
Packaging Group	I; II; III
HS Code	2934999090

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 9
CAS#:60838-50-8 (2E)-3-Methoxya... CAS#:127-09-3 Sodium acetate CAS#:2719-23-5 2-acetamidothiazole CAS#:58822-97-2 2-Azidothiazole
CAS#:3034-53-5 2-Bromothiazole CAS#:292638-85-8 acrylic acid me... CAS#:28142-85-0 2-(2,5-dimethyl... CAS#:97-97-2 Dimethylchloroacetal
CAS#:40916-19-6 2-chloral-1-met...
DownStream 10
CAS#:109172-21-6 3-(1,3-thiazol-... CAS#:37422-56-3 5-methyl-4-(2-t... CAS#:557-30-2 glyoxime CAS#:57738-11-1 1-(6-methylimid...
CAS#:34042-85-8 Sudoxicam CAS#:37762-99-5 4-Chloro-N-(1,3... CAS#:5448-49-7 2-(2-Chloroacet... CAS#:14954-35-9 Urea,N-phenyl-N...
CAS#:14901-16-7 1-phenyl-3-(2-t... CAS#:14954-36-0 Urea,N-methyl-N...

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2934100090
Summary	2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

J. Med. Chem. 51 , 6740-51, (2008)

The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared ...

Design, synthesis, and evaluation of potential inhibitors of nitric oxide synthase.

Bioorg. Med. Chem. 16 , 6193-206, (2008)

Selective inhibitors of neuronal nitric oxide synthase (nNOS) were shown to protect brain and may be useful in the treatment of neurodegenerative diseases. In this context, our purpose has been to des...

Effects of L-arginine, mirabegron, and oxybutynin on the primary bladder afferent nerve activities synchronized with reflexic, rhythmic bladder contractions in the rat.

Neurourol. Urodyn. 34(4) , 368-74, (2015)

We measured single-unit mechanosensitive afferent activities (SAAs) during reflexic, rhythmic bladder contractions (RBCs), and examined whether L-arginine, an NO substrate, and mirabegron, a β3-adreno...

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

thiazole-2-amine

EINECS 202-511-6

usafek-p-5501

2-amino-1,3-thiazole

Aminothiazole

1,3-Thiazol-2-amine

BASEDOL

2-Aminothiazole

ABADOLE

2-thiazolylamine

2-amino-thiazole

aminothiazol

RP 2921

2-Thiazolamine

THIAZYLAMINE

Abadol

MFCD00005325

thiazol-2-amine

cp1585

2-AMINO THIAZOLE

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What are the upstream materials of 1,3-thiazol-2-amine?

A: Related upstream materials(CAS) of 1,3-thiazol-2-amine: 60838-50-8;127-09-3;2719-23-5;58822-97-2;3034-53-5;292638-85-8;28142-85-0;97-97-2;40916-19-6.

Q: What are the downstream products of 1,3-thiazol-2-amine?

A: Related downstream products(CAS) of 1,3-thiazol-2-amine: 109172-21-6;37422-56-3;557-30-2;57738-11-1;34042-85-8;37762-99-5;5448-49-7;14954-35-9;14901-16-7;14954-36-0.

Q: What is the InChIKey of 1,3-thiazol-2-amine?

A: InChIKey of 1,3-thiazol-2-amine is RAIPHJJURHTUIC-UHFFFAOYSA-N.

Q: What is the polar surface area (PSA) of 1,3-thiazol-2-amine?

A: Polar surface area (PSA) of 1,3-thiazol-2-amine is 67.15000.

Q: What is the molecular weight of 1,3-thiazol-2-amine?

A: Molecular weight of 1,3-thiazol-2-amine is 100.142.

Q: What is the melting point of 1,3-thiazol-2-amine?

A: Melting point of 1,3-thiazol-2-amine is 91-93 °C(lit.).

Q: What English synonyms does 1,3-thiazol-2-amine have?

A: English synonyms of 1,3-thiazol-2-amine: thiazole-2-amine, EINECS 202-511-6, usafek-p-5501, 2-amino-1,3-thiazole, Aminothiazole, 1,3-Thiazol-2-amine, BASEDOL, 2-Aminothiazole, ABADOLE, 2-thiazolylamine, 2-amino-thiazole, aminothiazol, RP 2921, 2-Thiazolamine, THIAZYLAMINE, Abadol, MFCD00005325, thiazol-2-amine, cp1585, 2-AMINO THIAZOLE.

Q: What is the CAS number of 1,3-thiazol-2-amine?

A: CAS number of 1,3-thiazol-2-amine is 96-50-4.

Q: What is the SMILES notation of 1,3-thiazol-2-amine?

A: SMILES notation of 1,3-thiazol-2-amine is Nc1nccs1.

Q: What is the safety information for 1,3-thiazol-2-amine?

A: Safety information for 1,3-thiazol-2-amine: S26-S36/37-S39.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

Henan Tianfu Chemical Co., Ltd.

Zhongshan Xingrui Chemical Co. , Ltd.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 2-Aminothiazole
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-Aminothiazole
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 96-50-4
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: 2-Aminothiazole
Price: ￥Inquiry/25kg
Purity: 99.0%
Delivery: Inquiry
Contact: Wang Jie
Email: 3096638339@qq.com

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2-Aminothiazole suppliers

Price: ￥83/100g

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