Advanced Synthesis & Catalysis

Palladium (II)??Catalyzed Domino Reaction of 2??(1??Alkynyl)??2??alken??1??ones with Nucleophiles: Scope, Mechanism and Synthetic Application in the Synthesis of 3, 4?? …

Y Xiao, J Zhang

Index: Xiao, Yuanjing; Zhang, Junliang Advanced Synthesis and Catalysis, 2009 , vol. 351, # 4 p. 617 - 629

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Citation Number: 47

Abstract

Abstract: Described herein is the development of a palladium (II)-catalyzed two-or three- component reaction of 2-(1-alkynyl)-2-alken-1-ones with nucleophiles and allylic chlorides. Various types of nucleophiles such as O-, N-, C-based nucleophiles and olefin-tethered O-, N-, C-based nucleophiles were investigated. The scope, mechanism and application of this Pd (II)-catalyzed domino reaction were studied. In these transformations, the palladium ...