Tetrahedron

The total synthesis of chlorophyll a

…, JM Beaton, F Bickelhaupt, R Bonnett, P Buchschacher…

Index: Woodward, Robert Burns; Ayer, William A.; Beaton, John M.; Bickelhaupt, Friedrich; Bonnett, Raymond; Buchschacher, Paul; Closs, Gerhard L.; Dutler, Hans; Hannah, John; Hauck, Fred P.; Ito, Sho; Langemann, Albert; Le Goff, Eugene; Leimgruber, Willy; Lwowski, Walter; Sauer, Juergen; Valenta, Zdenek; Volz, Heinrich Tetrahedron, 1990 , vol. 46, # 22 p. 7599 - 7659

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Citation Number: 98

Abstract

The total synthesis of chlorophyll a starting from Knorr's pyrrole (1) is described with full experimental detail. Forty six stages are involved to reach the target molecule, chlorin e6 trimethyl ester (46), from which the preparation of chlorophyll a has already been described. The four pyrroles which are required for rings A, B, C and D are elaborated largely by known reactions, although with considerable improvements. These pyrroles are manipulated to ...