European Journal of Pharmaceutics and Biopharmaceutics 2015-08-01

Bioceramic microneedles with flexible and self-swelling substrate.

Bing Cai, Wei Xia, Susanne Bredenberg, Hao Li, Håkan Engqvist

Index: Eur. J. Pharm. Biopharm. 94 , 404-10, (2015)

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Abstract

To reduce the effort required to penetrate the skin and optimize drug release profiles, bioceramic microneedle arrays with higher-aspect-ratio needles and a flexible and self-swelling substrate have been developed. Swelling of the substrate can assist in separating it from the needles and leave them in the skin as a drug depot. The preparation procedures for this bioceramic microneedle are described in the paper. Clonidine hydrochloride, the model drug, was released in a controlled manner by the microneedle device in vitro. Results showed that the microneedle array with a flexible and self-swelling substrate released the drug content faster than the array with a rigid substrate. Disintegration of the needle material and diffusion of the drug molecules are believed as the main control mechanisms of the drug release from these microneedle arrays. Ex vivo skin penetration showed that they can effectively penetrate the stratum corneum without an extra device. This work represents a progression in the improvement of bioceramic microneedles for transdermal drug delivery. Copyright © 2015 Elsevier B.V. All rights reserved.