Tetrahedron Letters

Nano crystalline ZnO catalyzed one pot multicomponent reaction for an easy access of fully decorated 4H-pyran scaffolds and its rearrangement to 2-pyridone nucleus …

P Bhattacharyya, K Pradhan, S Paul, AR Das

Index: Bhattacharyya, Pranabes; Pradhan, Koyel; Paul, Sanjay; Das, Asish R. Tetrahedron Letters, 2012 , vol. 53, # 35 p. 4687 - 4691

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Citation Number: 70

Abstract

A green and highly efficient protocol has been developed for the synthesis of 4H-pyran scaffolds installing a one-pot three-component coupling reaction of an aldehyde, malononitrile, and a 1, 3-diketo compound using nano structured ZnO as the catalyst in aqueous alcoholic medium. A greener method to synthesize 3, 4-dihydropyridin-2-one has also been developed by rearranging 4H-pyran derivatives in aqueous medium applying p ...