Synthetic Communications®

Methanesulfonic acid/SiO2 as an efficient combination for the synthesis of 2-substituted aromatic and aliphatic benzothiazoles from carboxylic acids

H Sharghi, O Asemani

Index: Sharghi, Hashem; Asemani, Omid Synthetic Communications, 2009 , vol. 39, # 5 p. 860 - 867

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Citation Number: 49

Abstract

Abstract Methanesulfonic acid/SiO2 (1 mL/0.3 g) was found to be as an expeditious mixture in the synthesis of 2-substituted aromatic and aliphatic benzothiazoles at 140° C using carboxylic acids. After a simple workup, benzothiazoles were obtained in good yields. Simplicity, use of widely available and diverse carboxylic acids, and easy handling of the reaction conditions are among the benefits of the method.