Organic & Biomolecular Chemistry 2007-08-21

Nicotinamide adenine dinucleotide: beyond a redox coenzyme.

Hening Lin

Index: Org. Biomol. Chem. 5 , 2541-2554, (2007)

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Abstract

ADP-ribosylation using nicotinamide adenine dinucleotide (NAD+) is an important type of enzymatic reaction that affects many biological processes. A brief introductory review is given here to various ADP-ribosyltransferases, including poly(ADP-ribose) polymerase (PARPs), mono(ADP-ribosyl)-transferases (ARTs), NAD(+)-dependent deacetylases (sirtuins), tRNA 2'-phosphotransferases, and ADP-ribosyl cyclases (CD38 and CD157). Focus is given to the enzymatic reactions, mechanisms, structures, and biological functions.