NAD+

Modify Date: 2024-01-02 19:30:48

NAD+ structure	Common Name	NAD+
	CAS Number	53-84-9	Molecular Weight	663.425
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₂₇N₇O₁₄P₂	Melting Point	140 - 142ºC
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS08	Signal Word	Warning

Use of NAD+

NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.

Name	NAD zwitterion
Synonym	More Synonyms

Description	NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.
Related Catalog	Research Areas >> Metabolic Disease Natural Products >> Saccharides and Glycosides
Target	Human Endogenous Metabolite
In Vitro	NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. NAD+ is the oxidized form of NADH[1]. NAD+ is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (Nadide) [2].
In Vivo	Oral NAD+ supplementation has been used to combat simple fatigue as well as such mysterious and energy-sapping disorders as chronic fatigue syndrome and fibromyalgia[3].
References	[1]. Viollet, B., et al., Cellular and molecular mechanisms of metformin: an overview. Clin Sci (Lond), 2012. 122(6): p. 253-70. [2]. Brandt, U., Energy converting NADH:quinone oxidoreductase (complex I). Annu Rev Biochem, 2006. 75: p. 69-92. [3]. Kussmaul, L. and J. Hirst, The mechanism of superoxide production by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria. Proc Natl Acad Sci U S A, 2006. 103(20): p. 7607-12.

Melting Point	140 - 142ºC
Molecular Formula	C₂₁H₂₇N₇O₁₄P₂
Molecular Weight	663.425
Exact Mass	663.109131
PSA	340.71000
LogP	-5.72

NAD+ MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UU3450000

CHEMICAL NAME :: Pyridinium, 3-carbamoyl-1-beta-D-ribofuranosyl-, hydroxide, 5'-ester with adenosine 5'- 5'-(trihydrogen pyrophosphate), inner salt

CAS REGISTRY NUMBER :: 53-84-9

BEILSTEIN REFERENCE NO. :: 3584133

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C21-H27-N7-O14-P2

MOLECULAR WEIGHT :: 663.49

WISWESSER LINE NOTATION :: T56 BN DN GN INJ FZ B- BT5OJ CQ DQ E1OPWOPWO1- BT5OTJ CQ DQ E- AT6KJ CVZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4333 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 ug/plate

REFERENCE :: ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 45,327,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M3384 No. of Facilities: 499 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 4168 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M3384 No. of Facilities: 1731 (estimated) No. of Industries: 5 No. of Occupations: 13 No. of Employees: 26664 (estimated) No. of Female Employees: 19782 (estimated)

Symbol	GHS08
Signal Word	Warning
Hazard Statements	H371
Precautionary Statements	P260
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn,F,Xi
Risk Phrases	R36
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	UU3450000
HS Code	29349990

Precursor 9
CAS#:58-68-4 NADH CAS#:1094-61-7 β-Nicotinamide ... CAS#:24558-92-7 ADENOSINE 5'-MO... CAS#:18784-01-5 N1-(2,3,5-Tri-O...
CAS#:78687-39-5 N1-(β-D-Ribofur... CAS#:78687-38-4 3-carbamoyl-1-(... CAS#:6450-77-7 1-[5-[[[[5-(6-A... CAS#:61-19-8 5'-Adenylic acid
CAS#:56-65-5 Adenosine triph...
DownStream 8
CAS#:36791-04-5 Ribavirin CAS#:22596-06-1 1H-Benzotriazol... CAS#:98-92-0 Nicotinamide CAS#:20762-30-5 [5-(6-aminopuri...
CAS#:61-19-8 5'-Adenylic acid CAS#:73-24-5 Adenine CAS#:58-64-0 Adenosine dipho... CAS#:119340-53-3 Cyclic ADP-ribose

HS Code	29349990

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b-Diphosphopyridine Nucleotide

DPN

beta-Diphosphopyrid

MFCD00036253

Coenzyme I Hydrate,oxidized form

Diphosphopyridine nucleotide

Cozymase Hydrate,oxidized form

β-Nicotinamide adenine dinucleotide

EINECS 200-184-4

β-Diphosphopyridine Nucleotide Hydrate,oxidized form

β-NAD Hydrate,oxidized form

Adenine-D-ribose-phosphate-phosphate-D-ribose-nicotinamide

b-Nicotinamide Adenine Dinucleotide

β-DPN Hydrate,oxidized form

Adenosine 5'-(Trihydrogen Diphosphate) P'®5'-ester with 3-(Aminocarbonyl)-1-b-D-ribofuranosylpyridinium hydroxide Inner Salt

Codehydrogenase

β-Nicotinamide Adenine Dinucleotide Hydrate,oxidized form

3-Carbamoyl-1-b-D-ribofuranosylpyridinium hydroxide 5'®5'-ester with Adenosine 5'-(Trihydrogen Pyrophosphate) Inner Salt

ARPPRN

b-NAD

Cozymase

beta-Diphosphopyridine nucleotide

β-NAD

β-Nicotinamide adenine dinucleotide hydrate

NAD

β-DPN

NAD+

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China
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China
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NAD+

Use of NAD+

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NAD+ Biological Activity

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MSDS

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HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

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