Rinsho Ketsueki 2011-05-01

[Chronic myelogenous leukemia complicated by drug-induced agranulocytosis].

Takafumi Nakao, Noriko Yoshida, Takahiko Nakane, Yoshiki Terada, Hirohisa Nakamae, Ki-Ryang Koh, Takahisa Yamane, Masayuki Hino

Index: Rinsho. Ketsueki. 52(5) , 278-81, (2011)

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Abstract

We describe a patient with chronic myelogenous leukemia (CML) who developed drug-induced agranulocytosis. A 75-year-old female was diagnosed with CML in December 2001. She had been receiving imatinib therapy for more than five years. In August 2007, she was hospitalized due to a severe neutropenia 10 days after colonoscopy. She was diagnosed as having agranulocytosis induced by colonoscopy premedication including scopolamine butylbromide and flumazenil. Severe neutropenia was resolved by G-CSF treatment without CML progression. Agranulocytosis in patients with CML is rare, but potentially lethal. Here, we report the clinical course in this patient.