Biochemical and Biophysical Research Communications 2013-05-10

Extracellular NAADP affords cardioprotection against ischemia and reperfusion injury and involves the P2Y11-like receptor

Zoubir Djerada, Hélène Peyret, Sylvain Dukic, Hervé Millart

Index: Biochem. Biophys. Res. Commun. 434(3) , 428-33, (2013)

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Abstract

• Extracellular NAADP promotes cardiac preconditioning via the P2Y11-like receptors. • P2Y11-like receptors are able to induce prosurvival kinase activation in rat cardiomyocyte. • NAADP is released during ischemia suggesting a paracrine survival role.