NAADP tetrasodium salt
NAADP tetrasodium salt structure
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Common Name | NAADP tetrasodium salt | ||
|---|---|---|---|---|
| CAS Number | 5502-96-5 | Molecular Weight | 744.39 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H27N6O18P3 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of NAADP tetrasodium saltNAADP, a nucleotide, is a Ca2+-mobilizing second messenger. NAADP is essential for initiation of Ca2+ signaling[1][2]. |
| Name | nicotinic acid-adenine dinucleotide phosphate |
|---|---|
| Synonym | More Synonyms |
| Description | NAADP, a nucleotide, is a Ca2+-mobilizing second messenger. NAADP is essential for initiation of Ca2+ signaling[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | NAADP tetrasodium (2.5-10 μM) 诱导细胞毒性 T 淋巴细胞中酸性细胞内储存的 Ca2+ 释放[2]。 NAADP tetrasodium (10 μM，30 分钟) 刺激细胞毒性 T 淋巴细胞中的溶细胞颗粒胞吐作用[2]。 |
| In Vivo | NAADP (0.181 mg/kg, i.v.) promotes autophagosome formation and protects the hepatocytes from injury in mice induced by LPS/GalN[3]. Animal Model: LPS/GalN induced liver injury mice model[3] Dosage: 3-30 mg/kg Administration: 0.181 mg/kg, i.v. Result: Promoted autophagosome formation in in hepatocytes. Showed higher levels of LC3II, p62, ATG5, and ATG7 in hepatocytes. |
| References |
[1]. Walseth TF, et al: From Discovery to Mechanism. Front Immunol. 2021 Sep 7;12:703326. |
| Molecular Formula | C21H27N6O18P3 |
|---|---|
| Molecular Weight | 744.39 |
| Exact Mass | 743.07500 |
| PSA | 397.05000 |
| InChIKey | QOTXBMGJKFVZRD-HISDBWNOSA-N |
| SMILES | Nc1ncnc2c1ncn2C1OC(COP(=O)(O)OP(=O)([O-])OCC2OC([n+]3cccc(C(=O)O)c3)C(O)C2O)C(O)C1OP(=O)(O)O |
| Storage condition | 20°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi |
| Risk Phrases | 36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
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Involvement of actin filament in the generation of Ca2+ mobilizing messengers in glucose-induced Ca2+ signaling in pancreatic β-cells.
Islets 4(2) , 145-51, (2012) Glucose is a metabolic regulator of insulin secretion from pancreatic β-cells, which is regulated by intracellular Ca(2+) signaling. We and others previously demonstrated that glucose activates CD38/A... |
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The N-terminal region of two-pore channel 1 regulates trafficking and activation by NAADP.
Biochem. J. 453(1) , 147-51, (2013) TPCs (two-pore channels) are NAADP (nicotinic acid-adenine dinucleotide phosphate)-sensitive Ca2+-permeable ion channels expressed on acidic organelles. In the present study we show that deletion of t... |
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Nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated calcium signaling and arrhythmias in the heart evoked by β-adrenergic stimulation.
J. Biol. Chem. 288(22) , 16017-30, (2013) Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most potent Ca(2+)-releasing second messenger known to date. Here, we report a new role for NAADP in arrhythmogenic Ca(2+) release in cardi... |
| NAADP tetrasodium salt |