Tetrahedron letters

A novel and green protocol for two-carbon homologation: a direct amino acid/K 2 CO 3-catalyzed four-component reaction of aldehydes, active methylenes, Hantzsch …

DB Ramachary, M Kishor, K Ramakumar

Index: Ramachary, Dhevalapally B.; Kishor; Ramakumar Tetrahedron Letters, 2006 , vol. 47, # 5 p. 651 - 656

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Citation Number: 53

Abstract

Two-carbon homologation is a very important transformation in synthetic organic chemistry and numerous methods 1 are available although most involve redox functional group transformations rather than carbon–carbon bond formation. In this regard, the development of two-carbon homologation through carbon–carbon bond formation using organocatalytic tandem methodology 2 can provide an expedient access to homologated products from simple starting materials.