International Journal of Pharmaceutics 2014-08-25

Multimeric grain-marked micelles for highly efficient photodynamic therapy and magnetic resonance imaging of tumors.

Ung Yeol Lee, Young Taik Oh, Dongin Kim, Eun Seong Lee

Index: Int. J. Pharm. 471(1-2) , 166-72, (2014)

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Abstract

Multimeric grain-marked micelles consisting of an inner core micelle (for Fe3O4 encapsulation) and outer multi-grain micelles (for chlorin e6 (Ce6, a model drug) encapsulation) were fabricated using a micelle-to-micelle conjugation method. Grain micelles (mono-thiol functionalized micelles) were chemically linked to the surface of the core micelle (multi-maleimide functionalized micelle). These micelles enable discrete compartments for Ce6 and iron oxide (Fe3O4) that enable a significantly increased in vivo photodynamic tumor inhibition while preserving high contrast magnetic resonance (MR) imaging of the tumor in vivo. Copyright © 2014 Elsevier B.V. All rights reserved.